Deep Learning-Based Differential Diagnosis of Major Depression and Bipolar Disorder Using Microglia-Cellular Sensors and Patient-Derived Small Extracellular Vesicles
Published in Scientific Reports, 2026
A deep learning framework using microglial cells as biosensors and DenseNet121 to differentiate major depressive disorder, bipolar disorder, and healthy controls from fluorescence microscopy images of patient-derived extracellular vesicles.
Recommended citation: J. E. Zambrano, A. Luarte, J. Contreras, J. P. Perez, L. Yantén-Fuentes, M. Prieto, P. Lazcano, U. Wyneken and C. A. Perez, "Deep Learning-Based Differential Diagnosis of Major Depression and Bipolar Disorder Using Microglia-Cellular Sensors and Patient-Derived Small Extracellular Vesicles," in Scientific Reports, vol. 16, no. 1, p. 11679, 2026, doi: 10.1038/s41598-026-47476-9.
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